Dr Jason Fung
Dr. Jason Fung, The Fasting Doctor, reveals the truth about the diabetes medication (Ozempic) taking Hollywood by storm for its weight loss benefits.
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Transcript
0:00I’ve got to talk to you about these um
0:01these new injections people are getting
0:03to lose weight yeah and the role that
0:05they must be playing in our hormone
0:06balances what are those bloody things
0:08called the gp1s gp1s there’s another
0:10name for it isn’t there yeah uh well
0:12it’s there’s the drug name which is uh
0:15OIC is the American name and these are
0:18all in a class called gp1s and
0:22essentially again very interesting
0:24because they
0:26essentially really reduce the appetite
0:30which goes to show you that and people
0:32lose weight like a lot of weight and
0:34they keep it off so I people that are
0:36using them yeah like a billionaire
0:38friend of mine that’s very big in a
0:41certain industry uses a Zen pick I know
0:44Elon Musk came out and said he said he
0:46used it yeah asmic as well um I don’t
0:50I’m not I I I don’t have any problem
0:52with the OIC because again if you think
0:54about it what it’s telling you the the
0:57lesson it’s teaching you about weight
0:59loss is that it’s not about controlling
1:01the calories because the Olympic doesn’t
1:04burn any calories it’s about controlling
1:06your hunger it’s about that one level
1:09deeper why are you taking so many
1:11calories so if you simply reduce the
1:13hunger you’re going to naturally eat
1:16fewer calories which is going to cause
1:18weight loss and that’s what this OIC
1:20does it really reduces your appetite to
1:22very low levels how it it’s it’s it’s
1:26this this hormone called glp1 uh which
1:29is a natural sort of hormone it’s it’s
1:31released mostly in the intestines in the
1:33distal intestine and the small intestine
1:36and in response to certain foods it it
1:38goes up right so when you eat the body
1:41has a homeostatic mechanism so again
1:44remember you know people think that
1:46we’re just eating machines we eat until
1:48you know we explode sort of thing but
1:49that’s not true when you eat you
1:52actually activate the
1:54gp1 along with other hormones there’s
1:56multiple hormonal systems the gp1 is the
1:58one we’re interested in you activate gp1
2:01which then sets into motion the the the
2:04instructions for you to stop eating
2:06right so the act of eating sort of sets
2:09in motion that whole uh feedback loop to
2:12stop right so this is homeostasis which
2:13is trying to keep things at a proper
2:15level does that mean if you eat slower
2:18uh you’ll be less you’ll eat
2:20less there’s probably not more time to
2:23come out yeah probably it’s true um you
2:26know although it’s probably mostly true
2:28that if you eat really really fast that
2:31you don’t have enough time for the sort
2:32of homeostatic mechanisms to kick in so
2:35you don’t have enough time to stop
2:37eating um but the gp1s then go to the
2:40brain so they do certain things they
2:42help with digestion so they increase
2:44insulin response and then they go to the
2:46brain it crosses um the the the bloodb
2:49brain barrier so the gp1s gets released
2:53by the active eating goes into the brain
2:56crosses and is active um in the sort of
2:59midbrain brain area that tells your body
3:01to stop eating what these gp1s do of
3:04course is that it’s a uh it it gives you
3:07the hormone that tells you to stop
3:09eating even though you haven’t eaten
3:11it’s sort of that’s that’s the way the
3:13drug works so then what people tell you
3:15is that you know they’re just not hungry
3:17and if they’re not hungry then they
3:19don’t eat and when they don’t eat of
3:20course insulin Falls and you start to
3:22burn calories and lose weight but it
3:25wasn’t about controlling the calories it
3:28was about controlling the hunger that
3:31was the important part of it it’s the
3:33hormones right every successful drug to
3:36gain or lose weight right is a hormone
3:40it’s a hormone based because that’s
3:41instructions to the body food is energy
3:44and food is instructions you change the
3:47instructions and you you change the
3:48hormone people look at this through an
3:50evolutionary lens and say you know we
3:52just didn’t have this much food so it’s
3:53the abundance and um ease of access to
3:57food it’s the fridges that we now have
3:59it’s the the you know we never had
4:00fridges in our home so people point at
4:02it and go well that’s why people are
4:04getting gaining weight and you know
4:07we’re suffering with obesity at epidemic
4:08levels it’s just because there’s more
4:10Supply and the brain is taking advantage
4:13of it because once upon a time if we
4:15didn’t eat that jam and toast then we
4:18would have you know maybe not have been
4:20able to find food for another two weeks
4:22or something yeah I don’t think that’s
4:24the whole story because if you think
4:26about it uh and people again um make
4:30that assumption that we don’t have any
4:32control over our body fatness right so
4:36they say well it’s available so you’re
4:37going to take it right in fact that’s
4:40not true because we actually have a
4:43number of different uh hormones that
4:46tell us to stop eating okay so if you
4:50eat you cannot simply keep eating and
4:52eating and eating right if you go to an
4:54all you can eat buffet at some point you
4:56have to stop because you’re full right
4:59so there are systems very powerful
5:02systems within our body that tell us to
5:04stop eating so you eat food there are uh
5:08stomach stretch receptors for example so
5:10as your stomach stretches out it sends a
5:12signal to your brain and says stop
5:14eating if you eat a lot of protein uh it
5:18activates a hormone called peptide YY
5:20which tells you to stop eating if you
5:22eat a lot of dietary fat you activate a
5:25hormone called chosy ainin which again
5:28tells you to stop eating these are very
5:30powerful if you look in the wild there
5:32are no obese Antelope there are no obese
5:34Lions why because how much body fat your
5:38you carry is actually very important if
5:42you are obese as an antelope you’re
5:43going to get eaten if you are an obese
5:45lion you’re not going to catch any food
5:47so therefore it’s going to correct
5:48itself so if I overeat now my body will
5:51basically overcompensate by burning off
5:54the extra calories to it it absolutely
5:56so if you eat a huge meal right you eat
6:00you know you go to a big wedding or
6:01something like that you eat a huge meal
6:03the next day you’re probably not that
6:05hungry if you eat a giant steak so
6:08you’re activating all these satiety
6:10hormones peptide y y chosy ainin you’re
6:12eating all this food well you may not be
6:15hungry for the next day so that means
6:18that my body has some kind of Baseline
6:21weight yeah it will know whether you
6:24should eat more or less so there’s a
6:27this concept called the sort of body set
6:30weight which is a sort of thermometer
6:33that is your body sets a weight that you
6:35should be at and if you go above that
6:38weight or if you eat too much it will
6:41activate hormonal systems to bring it
6:43back down if you don’t eat enough it
6:45will also activate hormonal systems to
6:47bring it up so it’s like a thermostat
6:50that you set you have in your room for
6:52example you set the the room temperature
6:54if it’s too hot you’re the the room
6:57activates the air conditioning if it’s
6:59too cold it activates the heat your body
7:01actually acts the same way if you gain
7:03too much body fat your fat cells for
7:07example will produce leptin which is
7:09another hormone the leptin tells your
7:11body to stop eating that’s really
7:13interesting so in the case of obese
7:15people their set point must just be
7:17really high yes and that’s the Crux of
7:19the matter why is that set point being
7:22overridden just like if you have a room
7:24that’s too hot and you look and you say
7:26the thermometer is set for room
7:28temperature why is it so hot in here
7:31then you can say okay well what’s the
7:33problem and the problem is not you know
7:34heat in versus Heat out right that’s
7:36that’s a very simplistic way same thing
7:39if your body has too much body fat you
7:41got to then think about why are you
7:44overcoming the normal compensatory
7:47mechanisms that are happening that are
7:50stopping you from eating a lot of it
7:52relates to processing of foods of course
7:55so if you take out so remember I talked
7:57about stretch receptors in the stomach
8:00right so you eat natural natural foods
8:03there’s a natural break it stretches the
8:05stomach you stop eating well what’s one
8:08way pull out all the fiber process the
8:11foods turn it into say a very fine dust
8:14that means it’s absorbed extremely
8:16quickly into the blood stream so that
8:19means that pure you’ve got Pure
8:20carbohydrate basically mainlining it
8:23into your I like like an IV your glucose
8:27spikes way up your insulin spikes way up
8:29completely unnatural right if you eat
8:32pure carbohydrate instead of eating it
8:34with you know proteins and fats it’s
8:36going to go it’s going to shoot way high
8:38that’s unnatural and that’s going to
8:40overcome the
8:42natural tendencies for you to stop
8:45eating so you know you you’ve basically
8:47overcome that that that that protective
8:50mechanism because you’ve ultr processed
8:52the the carbohydrates if you don’t eat
8:55any protein if you don’t eat any fat
8:57you’re not activating peptide y y which
8:59is the satiety hormone you’re not
9:01activated kyin all of a sudden you’re
9:04eating you know 500 calories of white
9:07bread but you have zero satiety or if
9:10you drink a Coca-Cola or a soda for
9:12example I’ve always you know thought
9:15about this it’s like how can you take a
9:16th000 calories for example in one of
9:19those giant sodas you get at the ball
9:21game or something and don’t feel full at
9:24all whereas if you took a steak that’s
9:271,000 calories you’d be like I’m pretty
9:29full I don’t really feel like eating you
9:31drink the soda you’re like I really feel
9:33like eating some chips or popcorn or
9:36something why because it has zero
9:39satiety interesting so if I’m if I’ve
9:41got a baseball stadium what I want to do
9:44is I want to make sure people get a soda
9:47because then they’ll also buy the chips
9:50but if they just eat the chips you know
9:52maybe they won’t buy anything else but
9:53the soda is going to um increase my
9:57Revenue because it’ll basically he just
9:59passed right through them he’ll pass
10:00right through them they’re going to
10:01store all that energy as calories but
10:04they’re going to want more because you
10:05haven’t made them full right so the the
10:08whole point is that you have to think
10:10more than about the calories there’s
10:12more there than just the calorie story
10:14there’s this whole hormonal balance
10:16you’re saying that overeating isn’t just
10:17a choice it’s a hormon driven Behavior
10:19it’s a hormon driven Behavior I mean the
10:21whole thing about obesity is is quite
10:23interesting to me because if you think
10:25about obesity if you think about uh in
10:28the United states which is where I get a
10:30lot of my data from um you know you have
10:33maybe 70% of people overweight or obese
10:36and it’s going up every year it’s been
10:37going up every year since
10:391977 and if you think about that it
10:42tells you that the problem is not
10:45willpower the problem is not the people
10:48the problem is the environment that they
10:49find themselves in the food environment
10:51that they find themselves in because you
10:53can take an analogy say you have hundred
10:56children one of them fails well that
10:57might be the child they didn’t study
10:59what if 70 of them fail would you say
11:02it’s it’s each and every one of them’s
11:05fault or would you say it’s more likely
11:07that it’s the teacher’s fault I think
11:09it’s more likely that it’s the teacher’s
11:11fault so if we have a 100 Americans and
11:1370 of them are obese the problem is
11:16likely not an individual willpower
11:19problem the problem is likely that
11:22there’s something wrong with the message
11:24we’re giving people the information
11:25we’re giving people and the food
11:27environment that we’re finding ourselves
11:29in which is dominated by this sort of
11:31calories in calories out thinking and
11:34what’s really unfair of course is that
11:36we put the
11:37blame on the Obesity or overweight on
11:41the individual and we say well they let
11:44themselves go and they didn’t watch
11:45themselves they weren’t careful it’s
11:47their fault and that’s the stigma that
11:49comes with this whole calories in
11:51calories out thinking because we say
11:52it’s their fault because they could
11:54choose what they eat it’s like yes they
11:56could choose what they eat but they
11:58didn’t choose the food environment that
12:00is telling them to eat all this ultr
12:02processed food that is making all this
12:03ultr processed food available to them
12:05that is telling them that all this Ultra
12:07processed food is good for you if you
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